RecruitingNot ApplicableNCT04110041

Effects of Aerobic Exercise Intensity on Clinical & Neural Outcomes in Depressed Youth

Assessing the Clinical & Neural Outcomes in Depressed Youth Randomized to One of Two Intensities of Aerobic Exercise

Sponsor

The Royal's Institute of Mental Health Research

Enrollment

40 participants

Start Date

Aug 7, 2018

Study Type

INTERVENTIONAL

Conditions

Depression

Summary

This study will assess the effects of moderate vs. high intensity aerobic exercise, performed 3 times a week for 12 weeks under supervised conditions, on symptoms of depression, cognitive functioning and brain function in transitional aged youth (TAY: aged 16-24 years).

Eligibility

Min Age: 16 YearsMax Age: 24 Years

Inclusion Criteria6

Currently experiencing depression (MDD or PDD);
Free of pharmacotherapy (ie. antidepressant medication) for \>5 weeks;
Not currently engaging in regular moderate or vigorous intensity exercise;
Able to read/understand English;
Body mass index \[BMI\] \< 40;
Medically cleared to engage in aerobic exercise.

Exclusion Criteria9

Currently engaged in another exercise trial;
Another Axis I/II DSM-5 disorder, apart from co-morbid anxiety disorder(s);
Current or lifetime history of serious medical or neurological conditions;
Currently taking psychoactive drugs (occasional use of anti-anxiety medication permitted);
Regular user of nicotine products;
Unstable medical conditions, especially those that prevent exercise;
Exhibiting significant suicide risk;
MRI contraindications;
Currently pregnant or breastfeeding.

Interventions

BEHAVIORALAerobic Exercise

Thrice-weekly aerobic exercise sessions lasting \~45 minutes, for 12 consecutive weeks.

Locations(1)

University of Ottawa Institute of Mental Health Research

Ottawa, Ontario, Canada

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NCT04110041

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