RecruitingNCT04126148

Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)

Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Enrollment

350 participants

Start Date

Jul 4, 2019

Study Type

OBSERVATIONAL

Conditions

Coronary artery stenosis

Summary

The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Healthy Participants
Age: > 40y
No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system.
CAD Patients
Age > 18 y
Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.

Exclusion Criteria10

ALL participants:
General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam.
Regular nicotine consumption during the last 6 months.
Patients only
Vasoactive medication (e.g. nitro) during the 12 hours prior to the exam Contraindications to adenosine (2nd or 3rd A-V block, sinus node disease, asthma, bronchoconstrictive diseases).
Acute Coronary Syndrome (ACS), or previous Coronary Artery Bypass Surgery
Previous myocardial infarction within 1 month
Clinically unstable condition
Significant or uncontrolled arrhythmia