RecruitingNCT04127552

Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations

Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations (ITACA Study)

Sponsor

University of Roma La Sapienza

Enrollment

68 participants

Start Date

Jan 2, 2019

Study Type

OBSERVATIONAL

Conditions

Hypercortisolism Adrenal Incidentaloma Adrenal Tumor

Summary

The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS). Investigators hypothesize that adrenalectomy in selected patients, following the 2016 European Congress of Endocrinology (ECE) guidelines, can improve metabolic parameters and cardiovascular risks and features.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria1

Incidentally detected adrenal mass

Exclusion Criteria4

Patients with overt Cushing's syndrome, pheochromocytoma, Conn syndrome, adrenocortical carcinoma, late-onset congenital adrenal hyperplasia, adrenal metastasis and adrenal hemorrhage
Patients taking medications influencing glucocorticoid production or metabolism
Patients with psychiatric diseases or alcohol abuse
Pregnancy

Interventions

PROCEDUREAdrenalectomy

Adrenalectomy according to 2016 ESE guidelines

Locations(1)

Department of Experimental Medicine

Rome, Italy, Italy

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NCT04127552

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