RecruitingNCT04127552

Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations

Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations (ITACA Study)


Sponsor

University of Roma La Sapienza

Enrollment

68 participants

Start Date

Jan 2, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS). Investigators hypothesize that adrenalectomy in selected patients, following the 2016 European Congress of Endocrinology (ECE) guidelines, can improve metabolic parameters and cardiovascular risks and features.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at people who have a growth on their adrenal gland (a small gland near the kidney) that was found by accident during an unrelated scan — called an adrenal incidentaloma. The study investigates whether this growth affects the heart and metabolism by producing too much of the hormone cortisol. **You may be eligible if...** - You have an adrenal mass (growth on the adrenal gland) that was discovered incidentally (by accident during another scan) **You may NOT be eligible if...** - You have been diagnosed with Cushing's syndrome, pheochromocytoma, Conn syndrome, adrenal cancer, or certain other adrenal conditions - You take medications that affect cortisol production or metabolism - You have a psychiatric condition or alcohol abuse problem - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREAdrenalectomy

Adrenalectomy according to 2016 ESE guidelines


Locations(1)

Department of Experimental Medicine

Rome, Italy, Italy

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NCT04127552


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