RecruitingNot ApplicableNCT04153292

The ENCIRCLE Trial

SAPIEN M3 System Transcatheter Mitral Valve Replacement Via Transseptal Access


Sponsor

Edwards Lifesciences

Enrollment

900 participants

Start Date

Nov 12, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) for whom commercially available surgical or transcatheter treatment options are deemed unsuitable. Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

The ENCIRCLE Trial is testing a new transcatheter device called the SAPIEN M3 System for treating severe mitral valve regurgitation (MR) — a condition where the heart's mitral valve leaks blood backwards, reducing pumping efficiency and causing symptoms like shortness of breath and fatigue. This trial is specifically for patients who are not good candidates for standard surgical or transcatheter repair, meaning their condition is too risky or complex for the usual options. The SAPIEN M3 device is designed to be placed inside the damaged valve via a catheter inserted through the groin, without open-heart surgery. This approach could offer a treatment option for patients who currently have very limited choices. You may be eligible if: - You are 18 or older with severe mitral regurgitation (grade 3+ or higher) - You have NYHA functional class II or higher heart failure symptoms - Your heart team has determined standard surgical or transcatheter options are not suitable for you - Your heart failure management has been optimized and stable for at least 30 days You may NOT be eligible if: - Your heart anatomy makes the device delivery impossible - Your heart's pumping function is severely reduced (ejection fraction below 25%) - You have had a heart transplant - You have had a recent heart attack, stroke, or major cardiovascular procedure in the last 30–90 days - You have severe pulmonary hypertension, severe right heart failure, or significant liver disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICESAPIEN M3 valve and dock

During the procedure a SAPIEN M3 dock and a SAPIEN M3 valve will be implanted via transseptal approach.


Locations(68)

Heart Center Hospital

Huntsville, Alabama, United States

Banner University Medical Center

Phoenix, Arizona, United States

Saint Josephs Hospital Medical Center Dignity Health

Phoenix, Arizona, United States

TMC Healthcare

Tucson, Arizona, United States

Scripps Health

La Jolla, California, United States

Good Samaritan Hospital

Los Angeles, California, United States

Cedars-Sinai Medical Center

Los Angeles, California, United States

Kaiser Sunset LA

Los Angeles, California, United States

Saint Joseph Hospital

Orange, California, United States

California Pacific Medical Center

San Francisco, California, United States

UC Health Northern Colorado (Medical Center of the Rockies)

Loveland, Colorado, United States

Delray Medical Center

Delray Beach, Florida, United States

Cardiac & Vascular Institute Foundation

Gainesville, Florida, United States

Ascension St. Vincent's Hospital

Jacksonville, Florida, United States

Naples Community Hospital

Naples, Florida, United States

Sarasota Memorial Hospital

Sarasota, Florida, United States

Emory University

Atlanta, Georgia, United States

Piedmont Healthcare

Atlanta, Georgia, United States

Rush University Medical Center

Chicago, Illinois, United States

Northshore University Health System

Glenview, Illinois, United States

St. Vincent Heart Center of Indiana

Indianapolis, Indiana, United States

University of Kansas

Kansas City, Kansas, United States

Cardiovascular Research Institute of Kansas (CRIOK)

Wichita, Kansas, United States

Our Lady of the Lake Regional Medical Center

Baton Rouge, Louisiana, United States

Medstar Union Memorial Hospital

Baltimore, Maryland, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Brigham & Women's

Boston, Massachusetts, United States

Henry Ford

Detroit, Michigan, United States

Minneapolis Heart

Minneapolis, Minnesota, United States

Mayo Clinic

Rochester, Minnesota, United States

CentraCare

Saint Cloud, Minnesota, United States

Saint Luke's Kansas City

Kansas City, Missouri, United States

St. Patrick Hospital

Missoula, Montana, United States

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

Morristown Medical Center

Morristown, New Jersey, United States

Robert Wood Johnson University Hospital

New Brunswick, New Jersey, United States

University of Buffalo

Buffalo, New York, United States

Weill Cornell Medicine

New York, New York, United States

Carolinas Medical Center

Charlotte, North Carolina, United States

Novant Health and Vascular Institute

Charlotte, North Carolina, United States

The Christ Hospital

Cincinnati, Ohio, United States

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Mount Carmel East Hospital

Columbus, Ohio, United States

Oklahoma Heart Hospital

Oklahoma City, Oklahoma, United States

Oklahoma Heart Institute

Tulsa, Oklahoma, United States

UPMC Heart and Vascular Institute

Mechanicsburg, Pennsylvania, United States

Alleghany General Hospital

Pittsburgh, Pennsylvania, United States

Saint Thomas Health

Nashville, Tennessee, United States

Austin Heart

Austin, Texas, United States

HCA Houston Healthcare Medical (SCRI)

Houston, Texas, United States

UT Memorial Hermann

Houston, Texas, United States

Intermountain Medical Center

Murray, Utah, United States

Sentara Norfolk

Norfolk, Virginia, United States

Carilion Roanoke Memorial Hospital

Roanoke, Virginia, United States

University of Washington Seattle

Seattle, Washington, United States

University of Wisconsin

Madison, Wisconsin, United States

The Prince Charles Hospital

Chermside, Queensland, Australia

Royal Prince Alfred Hospital

Camperdown, Australia

Laval University

Québec, Quebec, Canada

St. Michael's

Toronto, Canada

St. Pauls

Vancouver, Canada

Shaare Zedek Medical Center

Jerusalem, Israel

Rabin Medical Center

Petah Tikva, Israel

Sheba Medical Center

Ramat Gan, Israel

Leiden University Medical Center

Leiden, Netherlands

Rotterdam Erasmus MC

Rotterdam, Netherlands

Saint Bartholomew's Medical Center

London, United Kingdom

Saint Thomas Hospital

London, United Kingdom

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NCT04153292


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