CAES for Internal Hemorrhoids and Rectal Prolapse

This study evaluates a procedure called CAES (Colonoscopic Assisted Endoscopic Sclerotherapy) for treating internal hemorrhoids and rectal prolapse. Hemorrhoids are swollen veins inside the rectum that can cause bleeding, discomfort, and prolapse. Sclerotherapy involves injecting a solution into hemorrhoidal tissue to shrink it. The study tests how safe and effective this endoscopic technique is for Grade I–III internal hemorrhoids and rectal prolapse, potentially offering an alternative to more invasive surgical procedures. You may be eligible if: - You have Grade I, II, or III internal hemorrhoids (with or without external hemorrhoids) and/or rectal prolapse - You have completed bowel preparation You may NOT be eligible if: - You have previously had anoscopic or endoscopic sclerotherapy - You have acute thrombotic hemorrhoids or Grade IV internal hemorrhoids - You have anal stenosis, perianal abscess, anal fissure, fistula, fecal incontinence, or other severe anal complications - You have inflammatory bowel disease - You have full-thickness rectal prolapse through the anus - You had acute diarrhea in the past 24 hours - You have high blood pressure that is not well controlled - You have had a stroke (cerebrovascular accident) - You have a blood clotting disorder - You are pregnant - You have a mental disorder - You have decompensated cirrhosis (advanced liver failure) Talk to your doctor to see if this trial is right for you.