Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer

This study is testing a radiation strategy for HPV-related throat cancer (oropharyngeal squamous cell carcinoma) that uses an intense targeted radiation boost followed by a shorter overall course of radiation — aiming to reduce treatment time while maintaining effectiveness. **You may be eligible if...** - You are 18 or older - You have a confirmed diagnosis of HPV-positive oropharyngeal (throat/tonsil) squamous cell carcinoma - Your cancer is early stage (Stage I–II under the AJCC 8th edition) - Your tumor is smaller than 30 cubic centimeters - You are planned for curative chemoradiation **You may NOT be eligible if...** - Your cancer is HPV-negative - You have previously received radiation to the head or neck - You have cancer that has spread to distant organs - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.