ATATcH Alternating Treatment Plans for Advanced Cancer

This study is testing whether alternating between two different treatment plans — rather than staying on one regimen — can better control advanced lung cancer (stage IV non-small cell lung cancer) or other advanced cancers, by preventing the cancer from becoming resistant to treatment. **You may be eligible if...** - You have advanced or stage IV non-small cell lung cancer (either squamous or non-squamous) - Or you have another eligible advanced cancer type included in the study - You have not received prior treatment for metastatic disease - Your tumor has been tested for specific genetic markers - You are in good general health (adequate organ function) **You may NOT be eligible if...** - Your cancer has spread to the brain in a way that is unstable or untreated - You have active autoimmune disease - You have had prior treatments that exclude you from the study arms - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.