Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy
Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy for Herniated Lumbar Discs Is There a Role? - A Randomized Control Trial
University of Missouri-Columbia
200 participants
Nov 21, 2019
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.
Eligibility
Inclusion Criteria4
- Presenting to the University of Missouri hospital system - including the University of Missouri Hospital and Missouri Orthopaedic Institute - with a clinical assessment indicative of a lumbar disc herniation
- Failed conservative treatment - rest, anti-inflammatory medications, physical therapy
- Radiculopathy present - positive tension signs or sensory/motor neurologic deficits present
- Recent MRI confirming single-level lumbar disc herniation corresponding to clinical evaluation
Exclusion Criteria5
- Concomitant spinal stenosis, segmental instability, or spondylolisthesis
- Previous surgery at the affected level or recurrent herniation
- Underlying disease that may affect response to steroids - immunocompromise, use of chronic steroids or immunosuppression
- Pregnancy - qualitative human chorionic gonadotropin (hCG) testing will be performed prior to enrollment
- Diagnosis of or symptoms concerning for cauda equina syndrome
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Interventions
Patients included in the treatment group will have their surgical site lavaged with dexamethasone at the end of their surgery.
Patients included in the placebo group will have their surgical site lavaged with sterile saline at the end of their surgery.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04182997