A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD

This study is testing a type of stem cell transplant for patients with sickle cell disease (SCD). Sickle cell disease is a genetic blood disorder that causes abnormally shaped red blood cells, leading to pain crises, organ damage, and other serious complications. The transplant uses stem cells from a half-matched (haploidentical) donor and involves removing certain immune cells (T-cells) to reduce the risk of rejection. Stem cell transplantation is currently the only known cure for sickle cell disease, but it requires a well-matched donor. This approach aims to expand donor options for patients who don't have a perfect match, potentially making a cure available to more people. You may be eligible if: - You are between 2 and 35 years old - You have sickle cell disease (SS, SC, or S0/S+ type) - You have had serious SCD-related complications such as stroke, frequent pain crises, chest syndrome episodes, or organ damage - A suitable half-matched donor is available You may NOT be eligible if: - You have poor performance status (Karnofsky/Lansky score below 70%) - You have donor-specific antibodies against your potential donor - You have major ABO blood type incompatibility with your donor - You have significant heart, kidney, lung, or liver problems - You are pregnant or not willing to use contraception - You have HIV infection or active uncontrolled hepatitis - You have had a prior stem cell transplant Talk to your doctor to see if this trial is right for you.