RecruitingNot ApplicableNCT04209218

Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery

Impact of Intraoperative Blood Pressure Management and Dexamethasone on Patient's Outcomes After Lung Cancer Surgery: A 2 × 2 Factorial Randomized Controlled Trial

Sponsor

Peking University First Hospital

Enrollment

1,988 participants

Start Date

Apr 7, 2020

Study Type

INTERVENTIONAL

Conditions

Surgery Lung Cancer Blood Pressure Management Dexamethasone Overall Survival Postoperative Complications

Summary

Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging. In addition to surgery, anesthetic management particularly intraoperative blood pressure management and use of dexamethasone may affect patients' early and long-term outcomes after surgery for NSCLC. This study aims to investigate the impact of intraoperative blood pressure management and dexamethasone administration on early and long-term outcomes in patients undergoing surgery for lung cancer.

Eligibility

Min Age: 50 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This trial studies how managing blood pressure during surgery — along with a steroid medication — affects recovery and outcomes in people having surgery for lung cancer. **You may be eligible if...** - You are 50–89 years old - You have been diagnosed with resectable non-small cell lung cancer (stages IA–IIIA) - You are scheduled for radical lung surgery expected to take more than 2 hours **You may NOT be eligible if...** - Your cancer is not suitable for surgery or you are only having a biopsy - Your cancer has recurred or spread - You have had other cancers - You use long-term steroids or immunosuppressants - You have uncontrolled high blood pressure, persistent atrial fibrillation, or a recent heart event - You have severe liver or kidney failure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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