Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
University of Florida
45 participants
Sep 2, 2021
INTERVENTIONAL
Conditions
Summary
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Oral oxycodone 5 mg orally
Intranasal oxytocin administration (48 IU)
Oxycodone 0 mg orally
Intranasal placebo administration
Oral oxycodone 2.5 mg orally
Locations(1)
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NCT04218409