RecruitingEarly Phase 1NCT04218409

Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination


Sponsor

University of Florida

Enrollment

45 participants

Start Date

Sep 2, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.


Eligibility

Min Age: 21 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called OxyCODONE 2.5 mg Oral Tablet, a drug called OxyCODONE 5 mg Oral Tablet, and others for people with pain. The study is currently recruiting participants at 1 location. People eligible for this study include aged 21 Years to 45 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOxyCODONE 5 mg Oral Tablet

Oral oxycodone 5 mg orally

DRUGOxytocin nasal spray

Intranasal oxytocin administration (48 IU)

OTHERPlacebo Oxycodone

Oxycodone 0 mg orally

OTHERPlacebo oxytocin

Intranasal placebo administration

DRUGOxyCODONE 2.5 mg Oral Tablet

Oral oxycodone 2.5 mg orally


Locations(1)

University of Florida

Gainesville, Florida, United States

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NCT04218409


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