A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease

This study compares two treatments for patients who have cancer that has spread to the brain: a chemotherapy wafer (GLIADEL) placed directly in the brain after surgery, versus a targeted radiation technique called stereotactic radiosurgery. The goal is to find which approach better controls brain tumors. **You may be eligible if...** - You are 18 or older - You have a solid cancer (such as lung or breast cancer) that has spread to the brain - You have 1 to 4 brain tumors, each no larger than 4 cm, and surgery is planned for at least one - You are in reasonably good health (Karnofsky score 60 or above) - Your expected survival is at least 3 months - Your blood clotting tests are normal **You may NOT be eligible if...** - You have had prior radiation to that area of the brain or whole-brain radiation - Your cancer is lymphoma, germ cell cancer, small cell lung cancer, or anaplastic thyroid cancer - You have a neurodegenerative disorder like dementia - Your tumor is larger than 4 cm - You are pregnant Talk to your doctor to see if this trial is right for you.