Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors
Immunophenotype Characterization of Circulating and Tumor Infiltrating Immune Cells in Malignant Brain Tumors.
Pietro Mortini, MD, Prof.
200 participants
Aug 1, 2022
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to characterize the circulating leukocyte profile and the immune T cells distribution within the tumor in patients with malignant brain tumors and to correlate these findings with the oncological outcome. Participants will be subjected to blood sampling before surgery and for 12 months of follow-up. Additional sampling and analysis will be performed on tumor samples.
Eligibility
Inclusion Criteria4
- Adult patients (≥18 years)
- Able to express informed consent
- With primary or secondary malignant brain tumor
- Requiring neurosurgical treatment (radiosurgery, stereotactic biopsy, surgery)
Interventions
Blood samples will be tested with flow cytometry in order to characterize leukocyte subpopulations and to evaluate the circulating immunophenotype
Immunohistochemical analysis will be performed on tumor samples in order to characterize immune T cells distribution within the tumor.
Locations(1)
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NCT05831631