RecruitingPhase 2NCT07132190

Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

A Double-Blind Phase II Randomized Study of Adaptively Delivered LINAC-Based Stereotactic Radiation for Volatile Brain Metastases With Same-Day Planning and Margin Reduction


Sponsor

Ayal A. Aizer, MD

Enrollment

60 participants

Start Date

Dec 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation treatment. The intent of this shorter time interval is to increase the likelihood that the brain metastases being treated remain fully within the high-dose radiation fields. Participants will be randomized to receive brain-directed stereotactic radiation with a 1mm margin or 0mm margin, have their simulation/radiation planning imaging on the same day that brain-directed stereotactic radiation is delivered, and have repeat simulation/radiation planning scans during the course of treatment if more than 2-3 days have elapsed since the most recent scans.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether stereotactic radiosurgery (a very precise form of radiation) can safely treat brain metastases that are growing quickly or are in a concerning location — rather than waiting or using whole-brain radiation. It is for people whose cancer has spread to the brain from another part of the body. **You may be eligible if...** - You are 18 or older - You have a solid cancer that has spread to the brain (brain metastases), confirmed by biopsy or imaging - Your brain metastasis is growing at least 1mm per week, is near a swollen area of the brain, or is close to a recent surgical cavity - You are in reasonably good functional health (Karnofsky score of at least 60) - Your doctor expects you to live at least 3–6 more months **You may NOT be eligible if...** - Your overall health condition makes radiation treatment unsafe - You are unable to complete the required assessments or follow-up Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONLinear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV

Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV


Locations(1)

Brigham and Women's Hospital / Dana-Farber Cancer Institute

Boston, Massachusetts, United States

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NCT07132190


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