Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)
Duke University
20,000 participants
Sep 1, 2020
INTERVENTIONAL
Conditions
Summary
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
To generate knowledge about the role of statins in older adults in whom risk/benefit for primary prevention is understudied,
To generate knowledge about the role of statins in older adults in whom risk/benefit for primary prevention is understudied,
Locations(106)
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NCT04262206