Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study

This preclinical research study is examining whether supplementing specific metabolites (small molecules involved in energy production) can restore mitochondrial function in patients suffering from septic shock. In septic shock, cells lose their ability to produce energy efficiently due to mitochondrial dysfunction, which contributes to organ failure. By restoring these key metabolites, researchers hope to improve cell survival and patient outcomes. You may be eligible if: - You are 18 years or older - You meet the SEPSIS-3 definition of septic shock: presumed sepsis with persistent low blood pressure requiring vasopressors and blood lactate above 2 mmol/L despite adequate fluid treatment - You are admitted to the ICU at Angers University Hospital (France) You may NOT be eligible if: - You are under 18 years old - You are subject to legal protection measures - You or your family have refused participation - You have a pre-existing mitochondrial disease - You have bone marrow aplasia - You are pregnant or recently gave birth Talk to your intensive care team about this study if you or a family member is hospitalized with septic shock at Angers University Hospital in France.