RecruitingNCT04310098
CADASIL Registry Study
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Registry Study
Sponsor
Bin Cai
Enrollment
1,000 participants
Start Date
Mar 9, 2020
Study Type
OBSERVATIONAL
Conditions
Summary
The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CADASIL , to optimize clinical management.
Eligibility
Min Age: 18 YearsMax Age: 85 Years
Inclusion Criteria6
- Sign informed consent.
- Age\>18
- Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin biopsy
- Asymptomatic NOTCH3 mutation carriers
- Relatives of CADASIL patients or carriers
- Unrelated healthy controls
Exclusion Criteria3
- Unable to cooperate with inspectors
- Serious systemic illness, such as heart, liver, kidney disease or major mental illness
- Contraindications for imaging examination
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04310098
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