MRI Study of Blood-brain Barrier Function in CADASIL
Peking University First Hospital
100 participants
Apr 1, 2021
OBSERVATIONAL
Conditions
Summary
Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB). The investigators aim to investigate whether the water exchange rate across the BBB, estimated with DP-pCASL, is changed in patients with CADASIL, and to analyze the association between BBB water exchange rate and MRI/clinical features in these patients.
Eligibility
Inclusion Criteria3
- Patients with CADASIL confirmed by gene or/and skin biopsy.
- The age range is 20-70 years old.
- There is no contraindication to MRI examination, and the informed consent is signed.
Exclusion Criteria3
- Combined with definite cerebrovascular disease, or combined with brain tumor, brain trauma and other causes of brain diseases.
- CADASIL is not confirmed.
- There are contraindications to examination or refusal to sign the informed consent.
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Interventions
All participants underwent an MR examination on a 3T whole-body Prisma MRI system (Siemens, Erlangen, Germany) with a 64-channel head coil, and a 7T whole-body MAGNETOM MR system (Siemens, Erlangen, Germany) using a 32-channel receive/birdcage transmit head coil (NOVA medical). DP-pCASL, Multi-delay pCASL (MD-pCASL) was acquired to evaluate BBB function and cerebral perfusion. T1-weighted magnetization-prepared rapid gradient echo (T1w-MPRAGE) was scanned at both 3T and 7T for registration in the post-processing workflow. T2-weighted fluid-attenuated inversion recovery (T2w-FLAIR) and T2\*-weighted gradient echo (T2\*w-GRE) were acquired at 7T for high-resolution structural images and evaluation of lesions.
Locations(1)
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NCT05902039