RecruitingNCT05902039

MRI Study of Blood-brain Barrier Function in CADASIL

Sponsor

Peking University First Hospital

Enrollment

100 participants

Start Date

Apr 1, 2021

Study Type

OBSERVATIONAL

Conditions

Cadasil Blood Brain Barrier Defect

Summary

Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB). The investigators aim to investigate whether the water exchange rate across the BBB, estimated with DP-pCASL, is changed in patients with CADASIL, and to analyze the association between BBB water exchange rate and MRI/clinical features in these patients.

Eligibility

Min Age: 20 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This observational study uses a specialized MRI technique to measure how well the blood-brain barrier (a protective filter between the bloodstream and the brain) is functioning in patients with CADASIL — a hereditary condition causing small vessel disease in the brain leading to strokes and cognitive decline. Researchers want to know if water exchange across this barrier is reduced in CADASIL patients compared to healthy people, and whether the degree of impairment matches disease severity. Eligible participants are 20–70 years old with a confirmed CADASIL diagnosis by gene test or skin biopsy, and no contraindications to MRI. Participation involves a single MRI brain scan and signing informed consent. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMRI

All participants underwent an MR examination on a 3T whole-body Prisma MRI system (Siemens, Erlangen, Germany) with a 64-channel head coil, and a 7T whole-body MAGNETOM MR system (Siemens, Erlangen, Germany) using a 32-channel receive/birdcage transmit head coil (NOVA medical). DP-pCASL, Multi-delay pCASL (MD-pCASL) was acquired to evaluate BBB function and cerebral perfusion. T1-weighted magnetization-prepared rapid gradient echo (T1w-MPRAGE) was scanned at both 3T and 7T for registration in the post-processing workflow. T2-weighted fluid-attenuated inversion recovery (T2w-FLAIR) and T2\*-weighted gradient echo (T2\*w-GRE) were acquired at 7T for high-resolution structural images and evaluation of lesions.