RecruitingNCT04352244

The Physiology of Human Brown Adipose Tissue

Sponsor

Beth Israel Deaconess Medical Center

Enrollment

40 participants

Start Date

Mar 5, 2020

Study Type

OBSERVATIONAL

Conditions

Obesity Adipose Tissue, Brown Adipose Tissue

Summary

Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories. Understanding more about differences between brown and white fat may allow us to develop new approaches to improve the body's metabolism.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study examines the physiology of human brown adipose tissue (BAT) — also called brown fat. Unlike regular (white) fat that stores energy, brown fat burns energy to generate heat. It has garnered interest as a target for treating obesity and metabolic disorders, but its function in humans is not well understood. This study recruits adults undergoing clinically indicated procedures at Beth Israel Deaconess Medical Center (BIDMC), and uses imaging and biopsies to characterize how brown fat behaves and responds to various stimuli. Participants undergo blood tests and imaging as part of the study. You may be eligible if: - You are between 18 and 75 years old - You are already scheduled for a clinically indicated procedure at BIDMC You may NOT be eligible if: - Your BMI is ≥40 kg/m2 - You have diabetes (HbA1c ≥6.5%) or significant liver, kidney, or blood disorders - You have had a recent infection, are on corticosteroids, or have active cancer (other than skin cancer) - You are pregnant or currently taking anticoagulants Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREFat biopsy

The fat biopsy is performed during a scheduled procedure at the Beth Israel Deaconess Medical Center (BIDMC). Routine preoperative procedures will be followed, including local anesthesia (numbing a particular region of the body) or general anesthesia (being put to sleep). Adipose tissue will be sampled from different depots depending on the procedure. For example, the surgeon will collect adipose tissue from the neck and supraclavicular depots from cervical spine, thyroid, and parathyroid procedures; perinephric fat from adrenalectomies, omental fat from abdominal procedures, and paraspinal fat from lumbar spine procedures. Up to 5 pieces of fat tissue weighing about three to six grams will be removed. All other aspects of the surgical procedure will proceed as planned. Samples will be prepared for subsequent laboratory analysis.

DIAGNOSTIC_TESTBlood sampling

A blood sample will be collected in the fasting state either during preoperative testing or in the preoperative area on the day of planned procedure for measurement of adipose functional markers (leptin, adiponectin) and insulin resistance (insulin, C-peptide), and measures of glycemia (glucose, hemoglobin A1c).

GENETICBlood sample for DNA analysis

Targeted resequencing of DNA to identify variants associated with adipose phenotypes will be performed.

Locations(1)

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

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NCT04352244

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