RecruitingPhase 3NCT07035093

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Sponsor

Eli Lilly and Company

Enrollment

586 participants

Start Date

May 29, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic Low Back Pain (CLBP)Obesity Overweight

Summary

The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo and a drug called Retatrutide for people with chronic low back pain (clbp), obesity, and other related conditions. The study is currently recruiting participants at 40 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRetatrutide

Administered SC

DRUGPlacebo

Administered SC

Locations(40)

MD First Research - Chandler

Chandler, Arizona, United States

Tucson Orthopaedic Institute - North Wyatt Drive

Tucson, Arizona, United States

Ark Clinical Research - Fountain Valley

Fountain Valley, California, United States

St Joseph Heritage Healthcare

Fullerton, California, United States

Clinical Research Institute

Los Angeles, California, United States

Artemis Institute for Clinical Research

San Diego, California, United States

Alpine Clinical Research Center

Boulder, Colorado, United States

K2 Medical Research - Daytona Beach

Daytona Beach, Florida, United States

Flourish Research - Miami, LLC

Miami, Florida, United States

IMA Clinical Research St. Petersburg

St. Petersburg, Florida, United States

Care Access - Tampa

Tampa, Florida, United States

Charter Research - Lady Lake

The Villages, Florida, United States

Conquest Research

Winter Park, Florida, United States

Cotton O'Neil Clinical Research Center

Topeka, Kansas, United States

Care Access - Lake Charles (Bayou Pines)

Lake Charles, Louisiana, United States

MedVadis Research Corporation

Waltham, Massachusetts, United States

Great Lakes Research Group, Inc.

Bay City, Michigan, United States

Clinvest Headlands Llc

Springfield, Missouri, United States

Center for Clinical Research

Winston-Salem, North Carolina, United States

Altoona Center For Clinical Research

Duncansville, Pennsylvania, United States

New Phase Research and Development

Knoxville, Tennessee, United States

FutureSearch Trials of Neurology

Austin, Texas, United States

Mercy Family Clinic

Dallas, Texas, United States

Houston Research Institute

Houston, Texas, United States

Sovah Clinical Research-River District

Danville, Virginia, United States

Investigaciones Medicas Imoba Srl

Buenos Aires, Argentina

CIPREC

Buenos Aires, Argentina

Centro Médico Viamonte

Buenos Aires, Argentina

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

Buenos Aires, Argentina

Fundación Respirar

Buenos Aires, Argentina

Centro de Investigaciones Clínicas Baigorria

Granadero Baigorria, Argentina

Centro Rosarino de Investigaciones Clinicas (CRICs)

Rosario, Argentina

Instituto Médico Catamarca IMEC

Rosario, Argentina

Centro de Diagnóstico y Rehabilitación (CEDIR)

Santa Fe, Argentina

Aggarwal and Associates Limited

Brampton, Canada

Winterberry Research Inc.

Hamilton, Canada

Bluewater Clinical Research Group Inc.

Sarnia, Canada

Care Access - Cape Breton

Sydney, Canada

Dr. Anil K. Gupta Medicine Professional Corporation

Toronto, Canada

Podlaskie Centrum Psychogeriatrii

Bialystok, Poland

View Full Details on ClinicalTrials.gov

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NCT07035093

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