RecruitingNot ApplicableNCT04368702

CONFIRM: Magnetic Resonance Guided Radiation Therapy

Clinical Onboard Utilization of Image Guided Radiation Therapy With Magnetic Resonance (CONFIRM): A Master Protocol

Sponsor

Brigham and Women's Hospital

Enrollment

70 participants

Start Date

May 1, 2021

Study Type

INTERVENTIONAL

Conditions

Gastric Cancer Invasive Breast Cancer

Summary

This research is being done to determine the safety and feasibility of using a type of radiation guided by magnetic resonance imaging (MRI) and chemotherapy to treat patients with gastric and breast cancer. The name of the radiation machine involved in this study is the MRIdian Linear Accelerator.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Participants must have histologically or cytologically confirmed malignancy requiring radiation
Age 18 years of older
ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
Ability to understand and the willingness to sign a written informed consent document.
Any further criteria listed in the specific disease site cohort

Exclusion Criteria4

History of allergic reactions attributed to gadolinium-based IV contrast
\-- Note: If patient will not receive contrast, this is not applicable and kidney function will not affect eligibility
Severe claustrophobia or anxiety
Participants who cannot undergo an MRI