Invasive Breast Cancer Clinical Trials

17 recruitingLast updated: June 17, 2026

There are 17 actively recruiting invasive breast cancer clinical trials across 5 countries. Studies span Phase 2, Not Applicable, Phase 1, Phase 3. Top locations include Boston, Massachusetts, United States, Houston, Texas, United States, Los Angeles, California, United States. Updated daily from ClinicalTrials.gov.


Invasive Breast Cancer Trials at a Glance

17 actively recruiting trials for invasive breast cancer are listed on ClinicalTrialsFinder across 6 cities in 5 countries. The largest study group is Phase 2 with 7 trials, with the heaviest enrollment activity in Boston, Houston, and Los Angeles. Lead sponsors running invasive breast cancer studies include Atossa Therapeutics, Inc., Brigham and Women's Hospital, and Alejandra García-Novoa.

Browse invasive breast cancer trials by phase

Treatments under study

About Invasive Breast Cancer Clinical Trials

Looking for clinical trials for Invasive Breast Cancer? There are currently 15 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Invasive Breast Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Invasive Breast Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting
Phase 2

Sacituzumab Govitecan In TNBC

Triple-Negative Breast CancerHER2-negative Breast CancerInvasive Breast Cancer+2 more
Massachusetts General Hospital260 enrolled5 locationsNCT04230109
Recruiting
Phase 2

Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient Patients

Triple-Negative Breast CancerInvasive Breast CancerVitamin D Deficiency
Wake Forest University Health Sciences50 enrolled1 locationNCT04677816
Recruiting
Not Applicable

Promoting Active Living Among People With Metastatic Breast Cancer

Metastatic Invasive Breast Cancer
University of Oklahoma38 enrolled1 locationNCT07238023
Recruiting
Phase 2

Tart Cherry Juice as a Dietary Supplement for the Prevention of Paclitaxel-Induced Neuropathy

Breast CancerBreast CarcinomaBreast Neoplasm+34 more
University of California, Davis86 enrolled1 locationNCT06268665
Recruiting
Phase 1

A Study of an Alternative Treatment Approach (Preoperative Radiotherapy, Then Mastectomy, Then Immediate Reconstruction Surgery) in People With T4 Breast Cancer

Breast CancerInvasive Breast Cancer
Memorial Sloan Kettering Cancer Center60 enrolled7 locationsNCT05412225
Recruiting
Not Applicable

CONFIRM: Magnetic Resonance Guided Radiation Therapy

Gastric CancerIn Situ Breast CancerInvasive Breast Cancer+3 more
Brigham and Women's Hospital70 enrolled2 locationsNCT04368702
Recruiting
Not Applicable

fREEDOM: REsonance for Early Detection Of Breast Cancer Metastases

Triple-Negative Breast CancerInvasive Breast CancerHER2-positive Breast Cancer
European Institute of Oncology145 enrolled1 locationNCT06328465
Recruiting

Organoids From Breast Cancer Patients Treated With Neoadjuvant Therapy

Invasive Breast Cancer
Istituti Clinici Scientifici Maugeri SpA240 enrolled1 locationNCT07260188
Recruiting

Prospective Breast Cancer Biospecimen Collection

Breast CancerInvasive Breast CancerCarcinoma in Situ of the Breast
Thomas Jefferson University200 enrolled1 locationNCT04074720
Recruiting
Phase 2

Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

Invasive Breast CancerStage III Breast CancerStage IIB Breast Cancer+4 more
Jonsson Comprehensive Cancer Center88 enrolled9 locationsNCT04553770
Recruiting
Phase 2

(Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer

Breast NeoplasmsHER2-negative Breast CancerInvasive Breast Cancer+1 more
Atossa Therapeutics, Inc.87 enrolled15 locationsNCT05607004
Recruiting
Phase 2

TRUDI: TDXD+Durva in HER2+/Low IBC

Breast CancerInvasive Breast CancerHER2-positive Breast Cancer+2 more
Filipa Lynce, MD63 enrolled3 locationsNCT05795101
Recruiting
Not Applicable

Magnetic Resonance Imaging of Breast Cancer

Breast CancerBreast Cancer Non-invasive Breast Cancer
Stanford University500 enrolled1 locationNCT01035112
Recruiting

Long-Term Follow-up Study of Early Stage Breast Cancer Patients Included in GEICAM Studies

Invasive Breast Cancer Early Stages
Spanish Breast Cancer Research Group8,000 enrolled73 locationsNCT03390894
Recruiting
Phase 3

Postoperative Radiotherapy in Breast Cancer- Concurrent or Sequential With Chemotherapy

Invasive Breast CancerStage III Breast CancerStage IIB Breast Cancer
Dr. Tabassum Wadasadawala858 enrolled5 locationsNCT06926543
Recruiting

Endoscopy/Robotic Assisted Nipple Skin Sparing Mastectomy

Breast Cancer Early Stage Breast Cancer (Stage 1-3)Breast Cancer Non-invasive Breast CancerHigh Risk Breast Carcinoma
Alejandra García-Novoa126 enrolled1 locationNCT06823414
Recruiting
Phase 2

Preoperative Partial Breast Irradiation in Early-Stage Breast Cancer

Breast CancerDuctal Carcinoma in SituInvasive Breast Cancer
Yonsei University47 enrolled1 locationNCT06677944