Perceptual Abnormalities and Their Malleability in BDD
Neural Mechanisms of Perceptual Abnormalities and Their Malleability in Body Dysmorphic Disorder
Centre for Addiction and Mental Health
146 participants
Dec 1, 2020
INTERVENTIONAL
Conditions
Summary
A core symptom of body dysmorphic disorder (BDD) is perceptual distortions for appearance, which contributes to poor insight and delusionality, limits engagement in treatment, and puts individuals at risk for relapse. Results from this study will provide a comprehensive mechanistic model of brain, behavioral, and emotional contributors to abnormal perceptual processing, as well as how malleable it is with visual modulation techniques. This will lay the groundwork for next-step translational perceptual retraining approaches.
Eligibility
Inclusion Criteria13
- males or females
- ages 18-40
- meet Diagnostic and Statistical Manual-5 (DSM-5) criteria for Body Dysmorphic Disorder
- have a Body Dysmorphic Disorder version of the Yale-Brown Obsessive-Compulsive Disorder Scale (BDD-YBOCS) score of ≥20
- primary appearance concerns of the face or head area
- medication naïve or medication free for at least 8 weeks prior to enrollment
- males or females
- ages 18-40
- have a score on the Dysmorphic Concern Questionnaire of ≥8 \[1 standard deviation (STD) above population norms\] - primary appearance concerns of the face or head area
- medication naïve or medication free for at least 8 weeks prior to enrollment
- Healthy controls: Inclusion
- Healthy males and females from any racial or ethnic background - ages 18-40
- have a score on the Dysmorphic Concern Questionnaire of <8
Exclusion Criteria21
- Body dysmorphic disorder: Exclusion
- concurrent major Axis I disorders including substance use disorders, aside from anxiety disorders or depressive disorders, as these comorbidities are very common and the sample would otherwise be non-representative; however BDD must be the primary diagnosis.
- lifetime: bipolar disorder or psychotic disorder.
- psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken on the days of the training or MRI scan
- current cognitive-behavioral therapy
- Subclinical body dysmorphic disorder: Exclusion
- meet full DSM-5 criteria for Body Dysmorphic Disorder
- current Axis I disorders including substance use disorders
- lifetime: bipolar disorder or psychotic disorder
- psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken on the days of the training or MRI scan
- current cognitive-behavioral therapy
- Healthy Controls: Exclusion
- Any current Axis I disorder
- lifetime: bipolar disorder or psychotic disorder
- Psychiatric medication
- All participants: Exclusion
- Neurological disorder
- Pregnancy
- Current major medical disorders that may affect cerebral metabolism such as diabetes or thyroid disorders - Current risk of suicide with a plan and intent
- Ferromagnetic metal implantations or devices (electronic implants or devices, infusion pumps, aneurysm clips, metal fragments or foreign bodies, metal prostheses, joints, rods or plates)
- Visual acuity worse than 20/35 for each eye as determined by Snellen close vision acuity chart (vision will be tested with corrective lenses if participant uses them).
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Interventions
Attentional instructions when viewing faces will be given
Faces will be presented of varying durations
Faces will be viewed without specific instructions
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04373629