RecruitingNot ApplicableNCT07016204

CBT Effects on Neurophysiological and Psychological Outcomes in Body Dysmorphic Disorder

A Randomized Controlled Trial Investigating the Effects of Cognitive-Behavioral Therapy on Neurophysiological and Psychological Outcomes in Individuals With Body Dysmorphic Disorder


Sponsor

Istanbul Nisantasi University

Enrollment

60 participants

Start Date

Jun 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial aims to investigate how a specific type of psychotherapy called Cognitive-Behavioral Therapy (CBT) can help people who experience Body Dysmorphic Disorder (BDD). BDD is a mental health condition where individuals become excessively preoccupied with perceived flaws in their physical appearance-flaws that are often unnoticeable to others. This distress can interfere significantly with their social, emotional, and daily functioning. The purpose of this study is to evaluate whether a 12-week CBT program can reduce symptoms of BDD and bring about measurable changes in brain activity, physiological stress responses, and patterns of visual attention when individuals view their own faces or appearance-related images. The researchers will use brainwave recordings (EEG), skin response sensors (GSR), and eye-tracking technology to assess these changes. In addition, participants will complete a set of questionnaires that measure depression, anxiety, emotion regulation, self-esteem, body image beliefs, and self-compassion. Sixty individuals will take part in the study. Thirty will receive CBT sessions once a week for 12 weeks, while the other thirty will be placed on a waitlist and offered treatment later. The study will compare how symptoms and neurophysiological responses change before and after therapy, and whether these changes differ between those who received immediate treatment and those who did not. The researchers hypothesize that CBT will reduce emotional distress, improve emotion regulation, and shift brain and body responses toward healthier patterns. This study will help identify how and why therapy works for BDD, and whether technologies like EEG and eye-tracking can be used to monitor treatment progress.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria6

  • Diagnosed with Body Dysmorphic Disorder (BDD) according to DSM-5 criteria
  • Right-handed (to ensure consistency in EEG lateralization analyses)
  • Minimum education level of high school (for questionnaire comprehension)
  • Normal or corrected-to-normal vision (for eye-tracking calibration)
  • Willingness to participate in all therapy and assessment sessions
  • Signed written informed consent

Exclusion Criteria8

  • Current use of psychotropic medication
  • Current or past psychotherapy within the last 6 months
  • Diagnosis of schizophrenia, bipolar disorder, or substance use disorder
  • Neurological disorders (e.g., epilepsy, traumatic brain injury)
  • Active suicidal ideation or recent suicide attempt (within past 12 months)
  • Pregnancy (due to possible changes in physiological readings)
  • Any uncorrected visual impairments or eye conditions preventing eye-tracking
  • Presence of metal implants or devices incompatible with EEG recording

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Interventions

BEHAVIORALCognitive-Behavioral Therapy

A structured 12-week psychotherapy protocol targeting maladaptive appearance-related beliefs and behaviors in individuals with Body Dysmorphic Disorder (BDD). The intervention involves individual sessions once per week (60 minutes) and incorporates techniques such as psychoeducation, cognitive restructuring, exposure and response prevention (ERP), mindfulness, and attentional retraining.


Locations(1)

Üsküdar University

Istanbul, Turkey (Türkiye)

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NCT07016204


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