Optimizing Y90 Therapy for Radiation Lobectomy

This study aims to optimize Y-90 radioembolization (a procedure that delivers radiation beads directly to liver tumors through blood vessels) for people with hepatocellular carcinoma (primary liver cancer) who need a specific approach called radiation lobectomy — where one side of the liver is treated to encourage the other side to grow before major surgery. **You may be eligible if...** - You have confirmed liver cancer (hepatocellular carcinoma), either by biopsy or meeting standard imaging criteria - Your liver disease is at the less advanced stage (Child-Pugh A) - The remaining portion of your liver after planned treatment is less than 40% of total liver volume - Your overall health is good (ECOG 0-1) - Your blood counts and kidney function are within acceptable ranges **You may NOT be eligible if...** - You are pregnant - You have significant cancer that has spread outside the liver - You have HIV, active hepatitis B or C (acute) - You are on dialysis or have another condition that makes Y-90 treatment unsafe - For Group 2 participants: you have contraindications to MRI (such as pacemakers, certain metal implants, severe claustrophobia, or kidney problems) Talk to your doctor to see if this trial is right for you.