HCC Clinical Trials

200 recruitingLast updated: July 17, 2026

There are 200 actively recruiting hcc clinical trials across 35 countries. Studies span Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1. Top locations include Shanghai, Shanghai Municipality, China, Guangzhou, Guangdong, China, Hangzhou, Zhejiang, China. Updated daily from ClinicalTrials.gov.


HCC Trials at a Glance

200 actively recruiting trials for hcc are listed on ClinicalTrialsFinder across 6 cities in 35 countries. The largest study group is Phase 2 with 76 trials, with the heaviest enrollment activity in Shanghai, Guangzhou, and Hangzhou. Lead sponsors running hcc studies include Fudan University, IRCCS Azienda Ospedaliero-Universitaria di Bologna, and Chang Gung Memorial Hospital.

Treatments under study

About HCC Clinical Trials

Looking for clinical trials for HCC? There are currently 40 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new HCC trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about HCC clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 200 trials

Recruiting

Multi-analyte Blood Test Clinical Trial

Liver CancerHepatocellular CarcinomaLiver Cirrhosis+1 more
Helio Genomics1,200 enrolled7 locationsNCT05199259
Recruiting

A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer

Pancreatic Ductal Adenocarcinoma (PDAC)CholangiocarcinomaHepatocellular Carcinoma (HCC)+3 more
City of Hope Medical Center1,000 enrolled1 locationNCT07224750
Recruiting
Phase 1

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

Colorectal, CancerEsophageal CancerGastric Cancer+9 more
Genentech, Inc.450 enrolled41 locationsNCT05581004
Recruiting
Phase 1Phase 2

ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

Liver CancerMetastatic Liver CancerLiver Neoplasms+3 more
Eureka Therapeutics Inc.12 enrolled4 locationsNCT04634357
Recruiting

Project for Multi-Omics-Based Early Detection of Hepatocellular Carcinoma (PROMETHEA Study)

Hepatocellular Carcinoma (HCC)
City of Hope Medical Center600 enrolled1 locationNCT07265271
Recruiting
Not Applicable

Outpatient Versus Inpatient Care Pathway for Intra-arterial Treatment of Primary Liver Cancer (CHOC)

Intrahepatic CholangiocarcinomaHepato Cellular Carcinoma (HCC)
University Hospital, Angers206 enrolled19 locationsNCT06990659
Recruiting
Not Applicable

CEUS vs. AMRI for HCC Detection in Patients With Indeterminate Liver Nodules

Hepatocellular CarcinomaHCC
University of Texas Southwestern Medical Center600 enrolled2 locationsNCT06184152
Recruiting
Phase 2

HAI or IV of Adebrelimab, Combined With Bevacizumab and HAI of FOLFOX for Advanced Unresectable Hepatocellular Carcinoma

Advanced Hepatocellular Carcinoma (HCC)
Sun Yat-sen University76 enrolled3 locationsNCT06737913
Recruiting
Phase 2

Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma

Hepatocellular CarcinomaHCC
University of California, Irvine35 enrolled1 locationNCT04472767
Recruiting
Phase 1Phase 2

A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

Hepatocellular Carcinoma (HCC)
Bristol-Myers Squibb198 enrolled64 locationsNCT07291076
Recruiting
Not Applicable

GPC3-Targeted PET/CT in Hepatocellular Carcinoma

Hepatocellular Carcinoma (HCC)Glypican-3GPC3-targeted PET/CT
The First Affiliated Hospital of Xiamen University40 enrolled1 locationNCT07677774
Recruiting

PSMA PET for the Staging and Management of Hepatocellular Carcinoma

Hepatocellular Carcinoma (HCC)
VA Office of Research and Development90 enrolled2 locationsNCT07019844
Recruiting
Phase 1

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

Head and Neck Squamous Cell Carcinoma (HNSCC)Non-small Cell Lung Cancer (NSCLC)Solid Tumor+7 more
Exelixis1,314 enrolled122 locationsNCT05176483
Recruiting
Phase 1

A Phase I, First in Human Study of CBA-1205, Anti-DLK1 Monoclonal Antibody in Patients With Advanced Solid Tumors, Hepatocellular Carcinoma (HCC), Melanoma, and Pediatric Cancer

Solid TumorsHepatocellular Carcinoma (HCC)Malignant Melanoma+1 more
Chiome Bioscience Inc.66 enrolled5 locationsNCT06636435
Recruiting
Phase 1Phase 2

A Phase Ib/II Trial to Evaluate the Efficacy and Safety of HH-009 for the Treatment of FGF19-positive Advanced or Unresectable HCC

Advanced or Unresectable Hepatocellular Carcinoma (HCC)
Huahui Health30 enrolled21 locationsNCT07547553
Recruiting

TACE and/or HAIC Combined With Molecular-targeted Therapy and Immunotherapy for HCC

Hepatocellular Carcinoma (HCC)
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University120 enrolled1 locationNCT07658833
Recruiting
Not Applicable

The Impact of Anaesthesia on Inflammation and NETosis in Hepatocellular Carcinoma Resection

Hepato Cellular Carcinoma (HCC)Sedation and AnalgesiaAblation Techniques
Iuliu Hatieganu University of Medicine and Pharmacy100 enrolled1 locationNCT07657897
Recruiting

A Multicenter Prospective Study on the Performance of Spectral CT for Evaluating Treatment Response After TACE in Hepatocellular Carcinoma

HCC - Hepatocellular CarcinomaCTTACE(Transcatheter Arterial Chemoembolization)
Zhongda Hospital121 enrolled1 locationNCT07351669
Recruiting

mSEPT9 Biomarker for Predicting Hepatocellular Carcinoma Occurrence in Patients With Cirrhosis

CirrhosisHepatocellular Carcinoma (HCC)Epigenomics+1 more
Central Hospital, Nancy, France400 enrolled1 locationNCT06778317
Recruiting
Phase 2

Y-90 Treatment Response Using Transarterial Radioembolization

Liver CancerHepatocellular CarcinomaPrimary Liver Cancer+3 more
Thomas Jefferson University30 enrolled1 locationNCT07145801