RecruitingNot ApplicableNCT04426786

Exercise & Brain Energetics in PD

The Effect of Exercise on Brain Energetics in Parkinson's Disease

Sponsor

Pacific Parkinson's Research Centre

Enrollment

40 participants

Start Date

Jan 26, 2021

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

There is increasing evidence that the usage and delivery of energy to the brain, known as brain energetics, is altered in people with Parkinson's disease (PD). This project will explore whether exercise has a positive impact on brain energetics using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) brain scanning in PD subjects. PD subjects will be scanned before and after a supervised exercise program to investigate the effect of exercise on brain energetics. In a separate study, the investigators will also scan healthy volunteers to compare brain energetics in the healthy brain with the brain energetics data in PD subjects acquired in this study.

Eligibility

Min Age: 40 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how exercise affects brain energy use in people with Parkinson's disease. Participants who currently don't exercise much will undergo brain scans before and after a period of exercise training, to see how physical activity changes the brain's metabolism. **You may be eligible if...** - You have been diagnosed with Parkinson's disease (idiopathic, not drug-induced) - Your Parkinson's is mild to moderate (Hoehn & Yahr stage I–III) - You currently exercise less than 120 minutes per week **You may NOT be eligible if...** - You have a different type of Parkinsonism (such as progressive supranuclear palsy or multiple system atrophy) - You have diabetes, high blood pressure, heart disease, kidney problems, or another significant chronic illness - You have had cancer in the last 5 years - You are pregnant or breastfeeding - You have severe claustrophobia or weigh more than 158kg (347 lbs) - You have a history of substance use problems, psychiatric disorders, or significant head injury Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERActive exercise

Thrice-weekly supervised intense aerobic exercise classes on cycle ergometers, in groups, for six months. Percentage of VO2 max will be used to regulate exercise intensity, based on an initial aerobic exercise test.

OTHERPassive exercise

Thrice-weekly supervised passive exercise classes consisting of stretching and/or yoga, in groups, for six months.