RecruitingNot ApplicableNCT04715984

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment


Sponsor

Vanderbilt University Medical Center

Enrollment

75 participants

Start Date

Jun 2, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study examines how certain brain circuits (between the cortex and the striatum) contribute to thinking and memory problems in Parkinson's disease. It takes place during deep brain stimulation surgery, where researchers can record brain activity while patients are awake. **You may be eligible if:** - You have been diagnosed with Parkinson's disease - You are scheduled for deep brain stimulation (DBS) surgery at Vanderbilt University Medical Center under local anesthesia - Your surgical plan involves electrode placement near the caudate (a part of the brain involved in thinking) - You are 40 years of age or older - You speak English and can participate in short tests during the procedure **You may NOT be eligible if:** - You are under 40 years old - You have a movement disorder other than Parkinson's disease - You are unable to understand or follow directions during testing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNeurophysiology recordings

Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated

OTHERNeural stimulation

Neural stimulation will be delivered during a gambling task and its impact on task performance quantified


Locations(1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

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NCT04715984


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