RecruitingNCT04439370

Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Sponsor

University of Minnesota

Enrollment

160 participants

Start Date

Oct 1, 2019

Study Type

OBSERVATIONAL

Conditions

Menopause Hypertension Blood Pressure Menopause, Premature

Summary

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.

Eligibility

Sex: FEMALEMin Age: 35 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how the nervous system controls blood pressure in women who went through menopause early (before age 45), to understand why they may have a higher risk of heart disease. **You may be eligible if...** - You are a woman aged 35–70 who went through menopause before age 45 - OR you are a premenopausal woman aged 35–49 (as a comparison group) - OR you went through menopause at the typical age (after 45) and are 50–70 years old **You may NOT be eligible if...** - You currently use tobacco or nicotine products - You have diabetes or asthma - You have had a stroke or significant heart or vascular disease - You have a known autonomic nervous system disorder - You are on certain blood pressure or hormone medications that would interfere with the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMicroneurography to measure muscle sympathetic nerve activity (MSNA)

Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves

DIAGNOSTIC_TESTBaroreflex sensitivity testing

Two arms of the baroreflex that will be tested in this study are sympathetic and cardiovagal. Static baroreflex is tested during baseline resting conditions and dynamic baroreflex is tested during Valsalva maneuvers.

DIAGNOSTIC_TESTSympathoexcitatory Maneuvers

Cold Pressor Test (CPT) and Upper extremity fatiguing contraction with post exercise circulatory occlusion (PECO) will be performed

DIAGNOSTIC_TESTBlood tests

Serum FSH, estrogen, progesterone, and testosterone will be measured