RecruitingNCT04439552

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus

Sponsor

Boston Children's Hospital

Enrollment

60 participants

Start Date

Oct 4, 2021

Study Type

OBSERVATIONAL

Conditions

Pain, Chronic Pain, Postoperative Pain, Acute Surgical Wound Keratoconus Cornea Surgical Injury Cornea Injury

Summary

Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

Eligibility

Min Age: 8 YearsMax Age: 35 Years

Inclusion Criteria12

CXL Group
Age 8-35 years
Clinical diagnosis of keratoconus and seeking CXL treatment
English speaking ability sufficient to comprehend consent with parental assistance
MRI compatible
Ability to lie still for an MRI session (60 minutes)
Control Group
Age 8-35 years
No diagnosis of keratoconus
English speaking ability sufficient to comprehend consent with parental assistance
MRI compatible
Ability to lie still for an MRI session (60 minutes)

Exclusion Criteria8

Claustrophobic
Weight \> 285 lbs (weight limit of the MRI table)
Significant medical history, including:
Current DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes
Magnetic implants or metal-containing tattoos on their chest or above
Pregnancy
History of contact lens wear
Any allergic response to a numbing eyedrop in the past

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