RecruitingNot ApplicableNCT04501133

Sensory-specific Peripheral Stimulation for Tremor Management

Sponsor

Shirley Ryan AbilityLab

Enrollment

180 participants

Start Date

Sep 1, 2020

Study Type

INTERVENTIONAL

Conditions

Parkinson's Disease Essential Tremor

Summary

The purpose of this study is to understand the neurophysiological mechanisms of peripheral electrical stimulation (PES) in modulating supraspinal tremorogenic input to motoneurons. For this purpose, the investigators will use transcutaneous PES, high-density electromyography (HD-EMG), transcranial magnetic stimulation (TMS), electroencephalography (EEG), magnetic resonance imaging (MRI), and neuromusculoskeletal modelling. This study will be carried out in both healthy participants and patients with essential tremor (ET) and Parkinson's disease (PD).

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests a wearable device that delivers gentle sensory stimulation (vibration and sound) to the wrist and arm to help reduce tremors in people with Parkinson's disease or essential tremor. It also includes healthy volunteers for comparison. **You may be eligible if...** - You are between 18 and 80 years old - You have a diagnosed tremor condition (such as Parkinson's disease or essential tremor) - You are able to understand and speak English - You have normal or corrected-to-normal hearing and vision **You may NOT be eligible if...** - You have a pacemaker or other electronic implant - You have a history of seizures, stroke, or severe arthritis in your hands or arms - You are pregnant - You have had a recent change in tremor medication (within the last 4 weeks) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEPeripheral electrical stimulation

Electrical stimulation will be delivered to forearm muscles with an electrical stimulator (Digitimer Ltd., Hertfordshire, UK) so that they generate forces opposed to those arising from the tremorgenic input.

DEVICESingle pulse TMS

Single-pulse TMS (spTMS) will be delivered with a TMS stimulator (MagPro X100 w/ MagOption, MagVenture, Farum, Denmark) and a figure-of-eight TMS coil. An MRI-based TMS navigation system will be used to navigate the TMS coil (Localite, St Augustin, Germany).