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RecruitingNot ApplicableNCT04505618

Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease

Sponsor

Johns Hopkins University

Enrollment

1,050 participants

Start Date

Oct 1, 2019

Study Type

INTERVENTIONAL

Conditions

Diabetic RetinopathyHypertension,EssentialRetinal Vein OcclusionRetinal Vascular Disorder

Summary

This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment.

Eligibility

Min Age: 18 YearsMax Age: 99 Years

Exclusion Criteria17

  • Both subjects with diseases and controls:
  • Children (age\<18)
  • Pregnant females
  • Developmentally delayed subjects
  • Subjects unable to provide informed consent
  • Inability to cooperate with tests and study instructions
  • Images with motion artifact or signal strength \< 7
  • History of glaucoma
  • History of age-related macular degeneration
  • History of any visually significant eye disease
  • History of proliferative diabetic retinopathy
  • History of any inflammatory disease
  • History of heart disease
  • History of thyroid disease.
  • Additional criteria for controls:
  • History of any type of Diabetes Mellitus
  • History of any type of Hypertension

Interventions

DEVICESwept-Source (SS) OCT Angiography

Non-invasive, minimal risk, ocular imaging study

DEVICESpectral-Domain (SD) OCT Angiography

Non-invasive, minimal risk, ocular imaging study

DEVICEFundus Imaging

Non-invasive, minimal risk, ocular imaging study

DEVICEAxial Length Measurement Device

Non-invasive, minimal risk, ocular imaging study

Locations(1)

Wilmer Eye Institute

Baltimore, Maryland, United States

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NCT04505618

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