RecruitingNCT04523909

Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery

Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery: the TURBO Study

Sponsor

Radboud University Medical Center

Enrollment

100 participants

Start Date

Dec 18, 2017

Study Type

OBSERVATIONAL

Conditions

Thoracic Aortic Aneurysm Postoperative Delirium Postoperative Cognitive Dysfunction

Summary

Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery. The aim of this study is to identify and unravel the biochemical (neuroinflammatory) pathways involved in postoperative delirium. Patient undergoing thoracic aortic surgery will have an external lumbar drain (ELD) in situ on the day before surgery. This ELD remains in place during and three days after surgery to reduce the risk on periprocedural spinal cord ischemia. Paired measurements of CSF and blood will be analyzed.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Competent patients ≥ 18 years
Patients who will undergo thoracic aortic surgery and will therefore receive an external lumbar drain as a standard of care procedure.

Exclusion Criteria5

Patients with meningitis/encephalitis/brain abscess within the last 6 months
Patients with other neurological conditions: brain injury (acute stroke, brain trauma or cerebral haemorrhage) within the last 3 months, known brain tumours, neurodegenerative disease or known pre-existing cognitive impairment (to a degree that would be compatible with mild cognitive impairment or more).
Brain or spinal surgery within the last 3 months
Active infection <2 weeks before surgery
Patients who object against storage of their body material for scientific reasons

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