Postoperative Cognitive Dysfunction Clinical Trials

22 recruiting

Postoperative Cognitive Dysfunction Trials at a Glance

22 actively recruiting trials for postoperative cognitive dysfunction are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Basel, Bad Nauheim, and Bad Nauheim. Lead sponsors running postoperative cognitive dysfunction studies include Heart and Brain Research Group, Germany, St Vincent's Hospital, and University Hospital, Basel, Switzerland.

Browse postoperative cognitive dysfunction trials by phase

Treatments under study

About Postoperative Cognitive Dysfunction Clinical Trials

Looking for clinical trials for Postoperative Cognitive Dysfunction? There are currently 22 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Postoperative Cognitive Dysfunction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Postoperative Cognitive Dysfunction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 22 trials

Recruiting

Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study

Cardiac Diseases Requiring SurgeryPostoperative Cognitive Dysfunction (POCD)
Shanghai Geriatric Medical Center634 enrolled1 locationNCT07483047
Recruiting

Optic Nerve Sheath Diameter and Cognitive Outcomes in Bentall Surgery

Postoperative Cognitive Dysfunction
Bursa Yuksek Ihtisas Training and Research Hospital100 enrolled1 locationNCT07452367
Recruiting
Not Applicable

Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients.

Postoperative DeliriumPostoperative Cognitive DysfunctionPreoperative Stress
Heart and Brain Research Group, Germany125 enrolled1 locationNCT05036538
Recruiting
Not Applicable

Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

Postoperative DeliriumPostoperative Cognitive DeclinePostoperative Cognitive Dysfunction
Heart and Brain Research Group, Germany100 enrolled1 locationNCT04493996
Recruiting

Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass

Postoperative Cognitive Dysfunction
Bakirkoy Dr. Sadi Konuk Research and Training Hospital106 enrolled1 locationNCT07000461
Recruiting

Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery

Postoperative DeliriumPostoperative Cognitive DysfunctionPostoperative Stroke
University Hospital, Basel, Switzerland500 enrolled4 locationsNCT05595954
Recruiting

Retrospective Evaluation of POCD Data of Studies From KAI, Charité - Universitätsmedizin Berlin

Postoperative Cognitive Dysfunction
Charite University, Berlin, Germany5,000 enrolled2 locationsNCT02832193
Recruiting

CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State

Perioperative/Postoperative ComplicationsPostoperative DeliriumPostoperative Cognitive Dysfunction+1 more
Beth Israel Deaconess Medical Center100 enrolled1 locationNCT06133842
Recruiting
Phase 3

Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery

Postoperative Pain ManagementPostoperative Cognitive DysfunctionHip Fracture+1 more
Romanian Society for Enteral and Parenteral Nutrition120 enrolled1 locationNCT07113483
Recruiting
Not Applicable

Kids With Iron Deficiency and Scoliosis

Perioperative/Postoperative ComplicationsAdolescent Idiopathic ScoliosisIron Deficiencies+4 more
Columbia University275 enrolled1 locationNCT06042699
Recruiting
Phase 2

The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study

Mild Cognitive ImpairmentPostoperative DeliriumPostoperative Cognitive Dysfunction
University of Michigan250 enrolled1 locationNCT05574400
Recruiting
Phase 4

The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

Postoperative DeliriumPostoperative Cognitive DysfunctionMajor Noncardiac Surgery
Medical University of Vienna1,332 enrolled2 locationsNCT05990790
Recruiting

Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool

Cognitive ImpairmentCognitive DeclinePostoperative Delirium+3 more
University Hospital, Basel, Switzerland475 enrolled1 locationNCT03360838
Recruiting

Bilateral Bispectral Index, Asymmetries and Post-operative Delirium

Postoperative DeliriumPostoperative Cognitive Dysfunction
IRCCS Azienda Ospedaliero-Universitaria di Bologna84 enrolled1 locationNCT06761573
Recruiting

Older People's Neurocognitive Recovery After Cardiac Surgery

Postoperative RecoveryPostoperative Cognitive DysfunctionCardiac Surgery
Karolinska Institutet220 enrolled1 locationNCT06469515
Recruiting
Not Applicable

Use of Transcranial Magnetic Stimulation in the Post-Operative Cognitive Dysfunction in Elderly

Postoperative Cognitive Dysfunction
University of Sao Paulo General Hospital12 enrolled1 locationNCT06658769
Recruiting
Not Applicable

Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients

DeliriumPostoperative Cognitive Dysfunction
West China Hospital890 enrolled1 locationNCT06176144
Recruiting
Not Applicable

CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.

The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and NeuroinflammationThe Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change
Chang Gung Memorial Hospital48 enrolled1 locationNCT06005363
Recruiting

Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery

Thoracic Aortic AneurysmPostoperative DeliriumPostoperative Cognitive Dysfunction
Radboud University Medical Center100 enrolled1 locationNCT04523909
Recruiting

Correlation Between Postoperative Cognitive-related Adverse Reactions and Brain Metabolomic Characteristics in Elderly Patients

POCD - Postoperative Cognitive Dysfunction
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University200 enrolled1 locationNCT05555693