Jump: MR Simulation For Radiation Therapy Master Protocol

This is a broad platform study that uses MRI-guided simulation to improve the planning of radiation therapy for patients with various cancers. Individual sub-studies focus on specific cancer types and are listed separately. **You may be eligible if...** - You are 18 or older with a confirmed malignancy that requires radiation therapy - Your general health is reasonable (ECOG score 0–2) - You are able to understand and sign a consent form - You meet the specific disease criteria for one of the sub-protocols **You may NOT be eligible if...** - You have had a serious allergic reaction to gadolinium-based contrast dye (if contrast MRI is required) - You are unable to undergo an MRI scan - You do not meet the specific eligibility requirements for any available sub-study Talk to your doctor to see if this trial is right for you.