Pain and Major Depressive Disorder

This study tests whether transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation technique — can help people who suffer from both treatment-resistant depression and chronic pain conditions like fibromyalgia or chronic fatigue syndrome. **You may be eligible if...** - You are between 18 and 75 years old and right-handed - You speak English fluently - You have been diagnosed with moderate-to-severe major depressive disorder that has not responded to at least 2 different antidepressant medications and psychotherapy - You have been diagnosed with fibromyalgia or chronic fatigue syndrome with pain lasting at least 3 months **You may NOT be eligible if...** - You are pregnant - You have an active plan or intent to harm yourself - You have previously had TMS treatment - You have a metal implant in or near your head (such as a cochlear implant or pacemaker near the scalp) - You have a skin infection or poor skin condition on your scalp Talk to your doctor to see if this trial is right for you.