MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)

This study compares two surgical techniques for removing part of the bowel (ileocolic resection) in people with Crohn's disease: one that preserves the blood vessels feeding the intestine (mesenteric-sparing) versus the standard technique that ties off higher blood vessels (high ligation). The goal is to see which approach better prevents the disease from coming back. **You may be eligible if...** - You are 18–65 years old - You have Crohn's disease limited to the area where the small and large intestines connect (ileocolic), with affected segment less than 30 cm - Your disease has not responded to medications, or you cannot tolerate continued treatment - You have not had a previous ileocolic resection **You may NOT be eligible if...** - You have Crohn's disease in multiple locations requiring additional surgery beyond ileocolic resection - You have had a prior ileocolic resection - You have had a recent serious health event (heart attack, active angina, or heart failure within 6 months) - You have hepatitis B, C, or HIV - You have had or currently have cancer (except localized skin cancer) - You are pregnant or breastfeeding - You have a history of significant autoimmune conditions other than Crohn's Talk to your doctor to see if this trial is right for you.