Oxalate Formation From Ascorbic Acid
University of Alabama at Birmingham
136 participants
Nov 15, 2021
INTERVENTIONAL
Conditions
Summary
The purpose of this basic research study is to determine the contribution of endogenous ascorbic acid (AA) turnover to urinary oxalate excretion in both normal BMI and obese adult non-stone formers and calcium oxalate stone formers. The studies proposed will use diets of known nutrient composition, a stable isotope of ascorbic acid (13C6-AA) and mass spectrometric techniques to quantify ascorbic acid turnover to oxalate.
Eligibility
Plain Language Summary
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Interventions
Subjects will be instructed to ingest a controlled diet low in oxalate for a total of 4 days
Subjects will be instructed to ingest 1mg/kg of carbon-13 ascorbic acid at breakfast, 2 days after initiating the low oxalate controlled diet.
Locations(1)
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NCT04603898