Kidney Stone Clinical Trials

54 recruitingLast updated: May 21, 2026

There are 54 actively recruiting kidney stone clinical trials across 13 countries. Studies span Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 3. Top locations include Chicago, Illinois, United States, Birmingham, Alabama, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Kidney Stone Trials at a Glance

54 actively recruiting trials for kidney stone are listed on ClinicalTrialsFinder across 6 cities in 13 countries. The largest study group is Not Applicable with 39 trials, with the heaviest enrollment activity in Chicago, Birmingham, and Dallas. Lead sponsors running kidney stone studies include University of Alabama at Birmingham, University of Chicago, and University of Kansas Medical Center.

Browse kidney stone trials by phase

About Kidney Stone Clinical Trials

Looking for clinical trials for Kidney Stone? There are currently 32 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Kidney Stone trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Kidney Stone clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 54 trials

Recruiting
Not Applicable

Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration Technology

Renal StonesKidney StonesUrolithiasis+1 more
Calyxo, Inc.150 enrolled3 locationsNCT07101809
Recruiting
Not Applicable

Oxalate-Driven Host Responses in Kidney Stone Disease

Kidney Stones
University of Alabama at Birmingham88 enrolled1 locationNCT05417568
Recruiting

Stone and Laser Therapies Post-Market Study (SALT)

Benign Prostate Hypertrophy(BPH)Ureteral Stones, Kidney StonesCalculi, Urinary+2 more
Boston Scientific Corporation238 enrolled5 locationsNCT06982235
Recruiting
Not Applicable

A Novel Ureteric Stent in Kidney Stone Patients and Oncology Patients Compared to a Conventional JJ Stent

OncologyKidney StoneCatheter Blockage
University of Southampton50 enrolled2 locationsNCT06815120
Recruiting
Not Applicable

Evaluation of the LithoVue Elite Ureteroscope With Intra-Renal Pressure Monitoring Technology: Examination of Surgeon Behavior and Post-operative Outcomes

NephrolithiasisKidney Stone
University of Kansas Medical Center80 enrolled1 locationNCT06576661
Recruiting
Not Applicable

Surgical Outcomes and Costs in Using the Shenzhen HugeMed 6.3 French Flexible Ureteroscope

Kidney Stones
University of Kansas Medical Center75 enrolled1 locationNCT07296835
Recruiting
Not Applicable

HoYAG vs TFL in miniPCNL With ClearPetra

NephrolithiasisKidney Stone
University of Kansas Medical Center150 enrolled1 locationNCT07087977
Recruiting
Phase 2

Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention

Kidney Stone
Insel Gruppe AG, University Hospital Bern99 enrolled1 locationNCT06111885
Recruiting
Not Applicable

Comparing Efficiency and Stone-Free Rates Mini PCNL vs Flex URS

Kidney StonesNephrolithiasisUrolithiasis
Northwestern University80 enrolled1 locationNCT07072598
Recruiting
Not Applicable

Safety and Efficacy of Combination of Tamsulosin 0.4 mg Plus Tadalafil 5mg Versus 2.5 mg

Kidney StoneUreteric Stone
Ain Shams University140 enrolled1 locationNCT07562282
Recruiting
Not Applicable

Effect of Complete Suction-Induced Collapse of the Renal Collecting System at the End of RIRS on Early Postoperative Outcomes

Kidney StonesNephrolithiasisRenal calculi
Kangdong Sacred Heart Hospital90 enrolled1 locationNCT07535281
Recruiting

Monogenic Kidney Stone - Genetic Testing

Rare Kidney Stone Diseases
Mayo Clinic6,000 enrolled1 locationNCT03305835
Recruiting

Effect of Negative Pressure Suction on Fluid Absorption and Infection in Flexible Ureteroscopy

Kidney Stones
Lanzhou University Second Hospital400 enrolled1 locationNCT07492147
Recruiting
Not Applicable

Oxalate Formation From Ascorbic Acid

Kidney Stone
University of Alabama at Birmingham136 enrolled1 locationNCT04603898
Recruiting
Not Applicable

Effect of a DASH-Style Diet on Urinary Risk Factors for Kidney Stone Disease

Kidney Stone
University of Alabama at Birmingham48 enrolled1 locationNCT06210009
Recruiting
Not Applicable

FANS-Assisted Mini-PCNL for Complex Renal Stones

Kidney Stones
The First Affiliated Hospital of Guangzhou Medical University30 enrolled1 locationNCT07332286
Recruiting
Early Phase 1

SGLT2i in Kidney Stones

Kidney Stones
University of Chicago32 enrolled1 locationNCT07055282
Recruiting
Not Applicable

Oxalate and Citrate

Kidney StoneNormal Controls
University of Chicago50 enrolled1 locationNCT05334979
Recruiting
Not Applicable

Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis

Kidney Stone
The Cleveland Clinic90 enrolled1 locationNCT05993546
Recruiting
Not Applicable

Oxalate and Citrate in Humans - Response to Citrate

HealthyKidney Stone
University of Chicago24 enrolled1 locationNCT06944223