Investigation of Subclinical Markers of Multiple Sclerosis
University of Split, School of Medicine
50 participants
Nov 23, 2020
OBSERVATIONAL
Conditions
Summary
Transcranial magnetic stimulation (TMS) studies reported consistent and substantial impairments in the central nervous system (CNS) in multiple sclerosis (MS). Studies of peripheral nervous system (PNS) function comprising electromyoneurography (EMNG) reported impairments of the PNS in MS that were less pronounced and inconsistent. Neurophysiological studies are generally small and cross-sectional and with the poor grouping of MS patients according to MS type. The objective of the study is to investigate clinical, neurophysiological, and immunological markers in relapsing-remitting MS patients, and in patients with relapsing-remitting MS treated with immunomodulation. The results of the study may contribute to a better understanding of the pathophysiology of multiple sclerosis and can provide guidance in the diagnosis and treatment of patients with relapsing-remitting MS.
Eligibility
Inclusion Criteria1
- Subjects with a documented diagnosis of relapsing-remitting MS according to the Mc Donald criteria (2005) and with EDSS achievement of 0-3.5 according to the modified Kurtzke's EDSS (Expanded disability status scale) for the assessment of neurological function and incapacity of patients with multiple sclerosis
Exclusion Criteria4
- Patients with metals in the body (e.g. pacemaker, dentures)
- Patients with new pregnancies (verbally confirmed)
- Patients with new head trauma
- Subjects unwilling to sign a consent or follow study procedures
Interventions
All groups will not have the same intervention. Interventions are listed and numbered for each group.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04604041