OH2 Injection in Combination With HX008 for Melanoma.

This study is testing a combination of two treatments for advanced melanoma: OH2 (an oncolytic virus injected directly into tumors) and HX008 (an immune checkpoint blocker). It targets patients whose melanoma has stopped responding to standard immunotherapy treatments. **You may be eligible if...** - You have confirmed stage III or IV melanoma or another advanced solid tumor - Your cancer has not responded to or you could not tolerate standard treatments, including PD-1 immunotherapy - You are in good enough health (ECOG ≤ 1) with an estimated survival of more than 3 months - Your prior treatment side effects have mostly resolved (grade 1 or better) - You have at least one measurable tumor **You may NOT be eligible if...** - Your cancer is well-controlled on current treatment - You have significant organ function problems - You are pregnant or breastfeeding - You have active brain metastases requiring immediate treatment Talk to your doctor to see if this trial is right for you.