Liver Transplantation in Patients With Unresectable Colorectal Liver Metastases

This study is exploring whether liver transplantation is a viable treatment option for carefully selected people with colorectal cancer that has spread only to the liver and cannot be surgically removed. Standard treatment does not include transplant for this condition, so this trial is testing a new approach. **You may be eligible if...** - You are 18 or older - You had colorectal cancer that was completely removed (R0 resection) previously - Your cancer has spread only to the liver and cannot be surgically removed - Your liver metastases responded to 1–2 lines of chemotherapy - You have been cancer-free elsewhere for at least 1 year before being listed for transplant - You are in good health (ECOG 0 or 1) **You may NOT be eligible if...** - Your cancer has spread outside the liver - Your tumor has a BRAF mutation - You are HIV or Hepatitis C positive - You are overweight (BMI ≥ 30) or have lost significant weight recently - You are pregnant - You have another active cancer Talk to your doctor to see if this trial is right for you.