RecruitingNot ApplicableNCT04636710

Refining Local-Regional Therapy for IBC

Refining Local-Regional Therapy for Inflammatory Breast Cancer (IBC)


Sponsor

Dana-Farber Cancer Institute

Enrollment

50 participants

Start Date

Jun 2, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This Feasibility study is trying to determine: * If Lymphoscintigraphy (imaging of the lymphatic drainage patterns) is effective in demonstrating the drainage to the sentinel lymph nodes in patients with inflammatory breast cancer. * The likelihood of identifying the sentinel lymph nodes in the operating room, using both blue dye and the radioactive substance used for lymphoscintigraphy. * The incidence of lymphedema (arm swelling which occurs after lymph node surgery) in women with inflammatory breast cancer * Outcomes for women with inflammatory breast cancer, whether or not the sentinel lymph nodes can be identified.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating and refining the surgical and radiation treatment approach for inflammatory breast cancer (IBC) — one of the most aggressive forms of breast cancer, characterized by rapid-onset redness, swelling, and skin changes affecting the breast. It is a registry study to collect data and improve treatment protocols. **You may be eligible if...** - You are a woman aged 18 or older - You have been diagnosed with Stage III inflammatory breast cancer - Your diagnosis meets all IBC criteria: symptoms started within 6 months, your breast shows redness/swelling/warmth covering at least one-third of the breast, and a biopsy confirmed invasive cancer - Your general health is acceptable (ECOG ≤ 2) - You have not yet started any cancer treatment before enrolling **You may NOT be eligible if...** - You have already started pre-surgery chemotherapy or other treatment before registering - Your cancer has spread to distant organs (Stage IV) - You have cancer in the other armpit lymph nodes Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELymphoscintigraphy

An imaging procedure using an injected radioactive substance or dye to identify lymph drainage A doctor reviews the images to identify the sentinel lymph nodes based on where the dye goes to first.


Locations(1)

Dana Farber Cancer Institute

Boston, Massachusetts, United States

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NCT04636710


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