RecruitingNot ApplicableNCT04694534

Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients

e-SEP Cognition: Effectiveness of a Remediation Program Via a "Serious Game" on the Cognitive Functions of Multiple Sclerosis Patients: Controlled, Randomized, Multicentric Trial

Sponsor

Lille Catholic University

Enrollment

150 participants

Start Date

Oct 8, 2021

Study Type

INTERVENTIONAL

Conditions

Multiple Sclerosis Memory Learning

Summary

The main goal of this study is to assess the effectiveness of a cognitive remediation program based on a "serious game" on the information processing speed evolution and the process of learning via episodic memory in multiple sclerosis patients.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria8

Relapsing-remitting or progressive multiple sclerosis people defined according to Mc Donald's criteria revised in 2005
Age between ≥ 18 and ≤ 65 years old
Cognitive complaint, with at least one deficient score at the initial neuropsychological examination (\<5th percentile of the reference group), one of the scores of which concerns at least one BICAMS test
Have not had a definite relapse for at least 6 weeks
Be at least 4 weeks away from a corticosteroid bolus
Lack of neuroleptic treatment
Patient with an Internet connection
Signed informed consent

Exclusion Criteria9

Severe cognitive deficit defined by obtaining a deficit score in more than six cognitive processes at the initial neuropsychological assessment.
Neuropsychological care
Inability to receive oral and written information
Inability to use the software (due in particular to motor and / or sensory difficulties),
Neurological or psychiatric comorbidity, other than MS and anxiodepressive syndrome
Patient with severe anxiodepressive syndrome (BDI\> 27)
Participation in an interventional study on cognitive functions
Patient under legal protection, guardianship or curatorship
Pregnant or breastfeeding women

Interventions

DIAGNOSTIC_TESTSerious game

The serious game is accessible via an online platform, on a tablet: 4 20-minutes activities sessions per week must be carried out. The program format in the serious game form makes possible to simultaneously understand a large number of cognitive functions.

DIAGNOSTIC_TESTUsual HAS care

The control group patients will follow the care they need, according to the HAS recommendations. Non-specific cognitive activities notebooks will be provided to them. They will be instructed to perform the 4 20-minutes sessions per week for 4 months.