RecruitingNCT04706234

Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases

Prospective Observational Study for the Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases


Sponsor

Kliniken Beelitz GmbH

Enrollment

350 participants

Start Date

Sep 1, 2017

Study Type

OBSERVATIONAL

Conditions

Summary

This is a non-interventional observational study designed to systematically record the results of routine laryngeal examinations and specific characteristics of dysphagia in patients with neurodegenerative disorders. The results of a fiberoptic / flexible endoscopic evaluation of swallowing (FEES) while performing a structured task protocol will be recorded. If available, laryngeal electromyography (EMG) results will also be recorded. In addition to the examination results, demographic and disease-specific data are collected, and two questionnaires, the Swallowing Disturbance Questionnaire for Parkinson's Disease (SDQ-PD) and the swallowing specific Quality Of Life Questionnaire (SWALQOL), are administered.


Eligibility

Min Age: 18 Years

Inclusion Criteria7

  • diagnosis of probable or possible multiple system atrophy according to current consensus criteria (Gilman et al. 2008) or
  • diagnosis of probable or possible PSP according to the the Movement Disorders Society (MDS) diagnostic criteria (Höglinger et al. 2017) or
  • diagnosis of Parkinson's disease according to the MDS diagnostic criteria (Postuma et al 2015)
  • Hoehn and Yahr Stage within the range of I-V or
  • diagnosis of motor neurone disease or
  • diagnosis of a neurodegenerative disease other than specified above
  • AND underwent laryngopharyngeal assessment according to the systematic task protocol during FEES (Warnecke et al. 2019).

Exclusion Criteria1

  • \- Patients who do not sign the consent form

Locations(16)

Department of Neurology and Department of ENT, Medical University Innsbruck

Innsbruck, Tyrol, Austria

Department of Neurology, Medical University of Ulm

Ulm, Baden-Wurttemberg, Germany

Movement Disorders Hospital - Kliniken Beelitz

Beelitz-Heilstätten, Brandenburg, Germany

Department of Neurology, Medical School Hannover

Hanover, Lower Saxony, Germany

Department of Neurology, University Hospital Münster

Münster, North Rhine-Westphalia, Germany

Department of Neurology, University Hospital Carl Gustav Carus

Dresden, Saxony, Germany

Department of Neueology Asklepios Klinik Stadtroda

Stadtroda, Thuringia, Germany

Asklepios Fachklinikum Stadtroda

Stadtroda, Thuringia, Germany

Asklepios Klinik Barmbek

Hamburg, Germany

Department of Neurology Asklepios Klinik Barmbek

Hamburg, Germany

Department of Neurology, Movement Disorders Unit, Medical Center Tel Aviv

Tel Aviv, Israel

IRCCS Istituto delle Scienze Neurologiche, Azienda USL di Bologna

Bologna, Italy

Department of Neurology, Gifu University Graduate School of Medicine

Gifu, Japan

Department of Neurology, Medical University Warsaw

Warsaw, Poland

Department of Neurology SNUCM

Seoul, South Korea

Unidad de Parkinson y Trastornos del Movimiento Instituto Clínic de Neurociencias, Hospital Clinic de Barcelona

Barcelona, Catalonia, Spain

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NCT04706234


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