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RecruitingNot ApplicableNCT04709900

CT Stress Myocardial Perfusion, Fractional Flow Reserve and Angiography in Patients With Stable Chest Pain Syndromes

DYnamic CT Stress Myocardial perfusioN, CT Fractional Flow Reserve and Coronary CT Angiography for Optimized treatMent Strategy In Patients With sTable Chest Pain syndromEs

Sponsor

Rigshospitalet, Denmark

Enrollment

2,000 participants

Start Date

Dec 3, 2021

Study Type

INTERVENTIONAL

Conditions

Heart FailureCardiovascular DiseasesStrokeCoronary Artery DiseaseAcute Myocardial InfarctionChest Syndrome

Summary

The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve (FFR-CT) and coronary CT angiography for optimized treatment strategy in patients with chest pain syndromes) is to determine the ability of combined anatomical and functional cardiac CT imaging to improve morbidity and mortality in patients with suspected or known ischemic heart disease.

Eligibility

Plain Language Summary

Simplified for easier understanding

This trial evaluates advanced CT imaging techniques (stress perfusion, fractional flow reserve, and angiography) to better diagnose heart disease in people with stable chest pain. **You may be eligible if...** - You have chest pain suspected or confirmed to be from heart disease - You need a non-urgent heart evaluation - You are 65 or older with chest pain, or 50–65 with typical angina and a risk factor or prior heart attack - You have had a prior coronary procedure (regardless of age) **You may NOT be eligible if...** - You have ongoing chest pain requiring emergency treatment - You had a heart attack (STEMI/NSTEMI) within the last 6 months - You have severe valve disease or severe heart failure (LVEF below 35%) - You have atrial fibrillation or language/mental barriers preventing informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTCT angiography, FFR-CT and stress CT myocardial perfusion

The study intervention team consists of a specialist in Cardiac CT imaging, an invasive cardiologist, a thoracic surgeon and a cardiology nurse specialist. Treatment strategy defined by the study team based on CT findings involve referral for percutaneous coronary intervention, Coronary Artery Bypass surgery and/or initiation of optimal medical therapy, in addition to potential supplementary diagnostic procedures.

Locations(1)

Department of Cardiology and Radiology, Rigshospitalet, The Heart Center, Capital Region of Copenhagen, University of Copenhagen

Copenhagen, Denmark

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NCT04709900

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