UPenn Observational Research Repository on Neurodegenerative Disease

This study builds a research registry of people with neurodegenerative diseases — conditions that cause the brain or nervous system to progressively deteriorate — to help researchers better understand these diseases over time. **You may be eligible if:** - You have been diagnosed with a neurodegenerative disease such as Alzheimer's disease, Parkinson's disease, ALS, frontotemporal dementia, or Lewy body disease - You have a family history of neurodegenerative disease, with or without symptoms - You are a healthy adult with no known neurological disease (to serve as a comparison) - You are 18 years of age or older **You may NOT be eligible if:** - You are under 18 years old - You have another condition that could complicate study findings (e.g., unrelated neurological, psychological, or serious medical conditions) - You are pregnant (though you may be able to resume participation after delivery) - You have metal implants that prevent you from having an MRI (you can still participate in other parts of the study) Talk to your doctor to see if this trial is right for you.