RecruitingNot ApplicableNCT07409207

Neurophysiology of Reward Signaling in Parkinson's Disease


Sponsor

Vanderbilt University Medical Center

Enrollment

75 participants

Start Date

Sep 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study examines how the brain processes reward signals in people with Parkinson's disease during deep brain stimulation (DBS) surgery — a procedure where electrodes are implanted in the brain to reduce movement symptoms. The goal is to understand the brain's response to rewards, which may help improve DBS outcomes. **You may be eligible if...** - You are 40 years old or older - You have been diagnosed with Parkinson's disease or another movement disorder - You are already scheduled for deep brain stimulation surgery at Vanderbilt University Medical Center under local anesthesia - The planned surgical path for your electrode will pass through a brain region called the caudate - You can participate in brief testing tasks during surgery - You speak English **You may NOT be eligible if...** - You are under 40 years old - You are unable to participate in intraoperative tasks — for example, if you cannot understand or follow instructions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNeurophysiology recordings

Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated

OTHERNeural stimulation

Neural stimulation will be delivered during a gambling task and its impact on task performance quantified


Locations(1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

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NCT07409207


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