Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
Identifying Modifiable PAtient Centered Therapeutics Frailty: An Observational Cohort Study
University of California, Los Angeles
250 participants
Sep 22, 2023
OBSERVATIONAL
Conditions
Summary
Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.
Eligibility
Inclusion Criteria2
- Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU
- ICU stay longer than 24 hours
Exclusion Criteria6
- Patients with muscular or mitochondrial diseases affecting muscle quality or mass
- Preexisting paralysis
- Absence of lower limbs
- Ongoing discussions about goals of care
- Transfers from a skilled nursing facility
- Children under the age of 18
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Interventions
2D ultrasound image collection
Inflammatory and nutritional biomarker analysis
A Frailty Index Questionnaire be completed by patients or their surrogates to determine the presence of frailty at ICU admission
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04717869