Frailty Clinical Trials

204 recruitingLast updated: June 19, 2026

There are 204 actively recruiting frailty clinical trials across 42 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Singapore, Singapore, Chicago, Illinois, United States, Milan, Italy. Updated daily from ClinicalTrials.gov.


Frailty Trials at a Glance

204 actively recruiting trials for frailty are listed on ClinicalTrialsFinder across 6 cities in 42 countries. The largest study group is Not Applicable with 100 trials, with the heaviest enrollment activity in Singapore, Chicago, and Milan. Lead sponsors running frailty studies include McGill University Health Centre/Research Institute of the McGill University Health Centre, National University of Singapore, and Nova Scotia Health Authority.

Treatments under study

About Frailty Clinical Trials

Looking for clinical trials for Frailty? There are currently 214 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Frailty trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Frailty clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 204 trials

Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting
Not Applicable

Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation

StrokeFrailtyAtrial Fibrillation (AF)+4 more
Guangdong Provincial People's Hospital200 enrolled1 locationNCT07441382
Recruiting
Not Applicable

Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients

Mobility LimitationFrailtyHospital Acquired Condition+1 more
The Cleveland Clinic3,000 enrolled5 locationsNCT05725928
Recruiting
Not Applicable

Prehabilitation for Ovarian Cancer Patients

ExerciseOvarian CancerPrehabilitation+4 more
Nova Scotia Health Authority108 enrolled1 locationNCT05364879
Recruiting
Not Applicable

The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With T2DM

Geriatric AssessmentFrailtyType2diabetes+1 more
Hospital de Clinicas de Porto Alegre220 enrolled1 locationNCT06469437
Recruiting

Ultrasound, Nutritional Status, and Outcomes in Surgical ICU

FrailtyNutritional StatusMuscle Thickness of the Quadriceps Femoris
Osijek University Hospital50 enrolled1 locationNCT07475767
Recruiting
Not Applicable

Optimizing Prevention of Hospital-Acquired Disability Through Multidomain Interventions

Frailty SyndromeAging
University of Milano Bicocca288 enrolled1 locationNCT06611228
Recruiting
Not Applicable

Investigating the Combined Effects of Protein, Blueberries, and Exercise on Cardiovascular Health and Frailty in Older Nova Scotians

Cardiovascular DiseaseFrailty
Nova Scotia Health Authority240 enrolled1 locationNCT06693271
Recruiting

Preoperative Oral Nutrition And Outcomes In Frail Elderly Patients With Femur Fractures

FrailtyMalnutritionFemoral Fractures
Duzce University228 enrolled1 locationNCT07463352
Recruiting

Frailty in Older Adults With Prostate Cancer: a Prospective Cohort Study

Prostate CancerFrailty at Older Adults
University of Limerick80 enrolled1 locationNCT07605936
Recruiting
Phase 2

Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV

FrailtyAgingHIV-1-infection+2 more
Massachusetts General Hospital100 enrolled2 locationsNCT06554717
Recruiting
Phase 2

TCM Formula vs. HMB in Pre-Frail Elders: Muscle Strength and Bone Status

pre frailtySarcopeniaOsteoporosis+2 more
Tri-Service General Hospital90 enrolled1 locationNCT07597850
Recruiting

Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients

SarcopeniaFrailtyNeuromuscular Blockade+2 more
Konya Meram State Hospital100 enrolled1 locationNCT07580144
Recruiting

CALLY Index, Frailty and SOFA-2 for Mortality Prediction in Geriatric ICU Patients

FrailtyCritical IllnessIntensive Care Unit ICU
Istanbul University - Cerrahpasa100 enrolled1 locationNCT07579728
Recruiting
Not Applicable

Twice vs Thrice Weekly Incident Hemodialysis in Elderly Patients

Quality of LifeFrailtyDialysis; Complications+1 more
Soonchunhyang University Hospital428 enrolled7 locationsNCT06141798
Recruiting

Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.

FrailtySeptic Shock
Centre Hospitalier de Lens200 enrolled5 locationsNCT05928767
Recruiting

Translation and Cultural Adaptation of the Groningen Frailty Indicator (GFI) in Patients With Hip Fracture

Frailty SyndromeHip Fractures
University of Thessaly89 enrolled1 locationNCT05091645
Recruiting

Frailty, Hip Fractures and Inflammatory Biomarkers

FrailtyHip FractureInflammatory Biomarkers
University of Thessaly200 enrolled2 locationsNCT06614478
Recruiting
Not Applicable

Managing Frailty Through Mobilization in Males and Female Inpatients With Cardiovascular Disease

Cardiovascular DiseasesFrailty
Université de Sherbrooke60 enrolled1 locationNCT06810661