Frailty Clinical Trials

197 recruiting

Frailty Trials at a Glance

184 actively recruiting trials for frailty are listed on ClinicalTrialsFinder across 6 cities in 42 countries. The largest study group is Not Applicable with 94 trials, with the heaviest enrollment activity in Singapore, Chicago, and Houston. Lead sponsors running frailty studies include McGill University Health Centre/Research Institute of the McGill University Health Centre, University of Iceland, and University of Leicester.

Treatments under study

About Frailty Clinical Trials

Looking for clinical trials for Frailty? There are currently 197 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Frailty trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Frailty clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 184 trials

Recruiting
Not Applicable

Preventing Frailty in Hospital Through Mobilizing

Frailty at Older Adults
Université de Sherbrooke80 enrolled1 locationNCT06802289
Recruiting
Not Applicable

A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF)

Kidney Disease, ChronicFrailtyKidney Failure
Seven Oaks Hospital Chronic Disease Innovation Centre54 enrolled2 locationsNCT06343727
Recruiting
Not Applicable

A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve Muscle Health in Older Adults

SarcopeniaFrailtyAging+3 more
Changi General Hospital40 enrolled1 locationNCT07205133
Recruiting
Not Applicable

Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore

Healthy AgeingFrailty in Older AdultsIntrinsic Capacity+1 more
Sengkang General Hospital600 enrolled1 locationNCT07477561
Recruiting
Not Applicable

Multicomponent Prehabilitation in Older Adults With Breast Cancer

Breast CancerSarcopeniaFrailty+2 more
Fundacion Miguel Servet90 enrolled1 locationNCT07531836
Recruiting

Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore

FrailtyLifestyleIntrinsic Capacity
National University Hospital, Singapore2,500 enrolled1 locationNCT07525583
Recruiting
Not Applicable

Frailty in Older Adults With Chronic Obstructive Pulmonary Disease (COPD) and Outcomes of the VIVIFRAIL Program

Chronic Obstructive Pulmonary Disease (COPD)Frailty
National Geriatric Hospital80 enrolled2 locationsNCT07519603
Recruiting

Plant-based Diets and Healthy Aging

SarcopeniaCognitive DeclineFrailty+1 more
National Health Research Institutes, Taiwan5,000 enrolled1 locationNCT07151365
Recruiting
Not Applicable

Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement

PrehabilitationFrailty SyndromeArthroplasties, Knee Replacement
University of Iceland50 enrolled1 locationNCT07465159
Recruiting
Not Applicable

Strength-based Tailored-Exercise Program at Home for Geriatric Patients

FrailtyGeriatrics
The University of Hong Kong256 enrolled1 locationNCT06820021
Recruiting
Not Applicable

Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults

Frailty at Older Adults
The Hong Kong Polytechnic University224 enrolled1 locationNCT07513701
Recruiting

The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP

FrailtyPostoperative Acute Kidney Injury
Lanyue Zhu1,000 enrolled1 locationNCT07030179
Recruiting
Not Applicable

Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty

Physical PerformanceFrailty at Older AdultsFunctional Capacity+3 more
Consorci Sanitari del Maresme262 enrolled1 locationNCT06925880
Recruiting

Frailty in Patient Undergoing Percutaneous Left Atrial Appendage Closure.

FrailtyTranscatheter Left Atrial Appendage Closure
Josep Rodes-Cabau500 enrolled1 locationNCT05257954
Recruiting
Not Applicable

A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults

Mild Cognitive ImpairmentFrailty at Older Adults
The Hong Kong Polytechnic University45 enrolled1 locationNCT07497334
Recruiting
Phase 3

Prehabilitation in Gynaecological Cancer Patients

Ovarian CancerEndometrial CancerOvarian Cancer Stage III+2 more
Charles University, Czech Republic64 enrolled1 locationNCT04789694
Recruiting
Not Applicable

Optimised Post-discharge Care in Older Patients After Surgery for Colon Cancer (ERAS 3.0)

Colon CancerFrailty
Copenhagen University Hospital at Herlev60 enrolled2 locationsNCT06802991
Recruiting

Ultrasound Indicators of Nutritional Status and Treatment Outcomes in Surgical Patients in the Intensive Care Unit

FrailtyNutritional StatusMuscle Thickness of the Quadriceps Femoris
Osijek University Hospital50 enrolled1 locationNCT07475767
Recruiting

Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults.

FrailtyTricuspid RegurgitationCardio-Renal Syndrome+1 more
Robert Bosch Medical Center100 enrolled1 locationNCT07464106
Recruiting
Not Applicable

MultidISciplinary Care paThway tailoRed on frAilty in Cancer Patients Referred to Outpatient paLliative Care

CancerFrailtyPalliative Care+4 more
Augusto Caraceni120 enrolled1 locationNCT07469761